Last, click OK, and your new Outlook signature will be ready to use for all email you have chosen to use it for. Select the name of your signature in the drop downs you would like it to apply to. Login to Windows with a new profile to rule out problem in Windows profile. Dont leave CTRL key, till it asks for the confirmation about safe mode. To rule this out, start Outlook in safe mode. You can find Outlook customization options in settings, or the gear icon on the right side of the top horizontal menu. Based on your description, Id like to confirm if you meant when your users clicked the Signature button, Outlook hung and users were not able to add a signature. Below that you will see the options for how the signature will be used (on new messages only, on replies/forwards only, or both). There is a possibility that some Add-in is causing the problem. Hi Andy Crook, Thank you for choosing Microsoft community.
![microsoft outlook 2016 email signature microsoft outlook 2016 email signature](https://global.discourse-cdn.com/spiceworks/original/4X/7/d/7/7d78f4591b3b8370221d72e47e59c52947c52d85.jpeg)
Press F3 to repeat the search until no more registry keys are found. Delete the key by right-clicking on the entry and selecting Delete. If prompted, select Yes in the User Account Control window. For example, in Windows, select File > Options > Mail > Signatures, then click the 'Email Signature' tab. The first drop down will allow you to select different email accounts (this will likely be unchanged). Press the Windows key + R to open a Run window.
![microsoft outlook 2016 email signature microsoft outlook 2016 email signature](https://global.discourse-cdn.com/spiceworks/original/4X/0/a/9/0a94d6ad88fd19ee669fb428bcb1f0d9a3cd9361.png)
In the top right of this screen you will also see drop down menus for how the signature will be used.
![microsoft outlook 2016 email signature microsoft outlook 2016 email signature](https://mycomputerworks.com/wp-content/uploads/2018/01/f44322e0-367e-415d-ac2b-0c44e2e7c959.jpg)
In the example below I have named the Signature “Steve – New Message”
![microsoft outlook 2016 email signature microsoft outlook 2016 email signature](https://i2.wp.com/www.technipages.com/wp-content/uploads/2014/07/Outlook-2016-Signatures-button.png)
In the ribbon bar above the new email, click Signatures this will open a drop down where you need to click Signatures again.Click New Email in the top left portion of the ribbon bar.